Unbiased Forward Genetic Screening with Chemical Mutagenesis to Uncover Drug-Target Interactions.

Horn M, Metge F, Denzel MS.

Methods Mol Biol. 2019

Chaperoning junior faculty: Institutional support and guidance can relieve challenges for early-career group leaders and improve academic performance.

Sawarkar R, Scherz-Shouval R, Denzel MS, Saarikangas J.

EMBO Rep. 2019

Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics.

Denzel MS, Lapierre LR, Mack HID.

Mech Ageing Dev. 2019

Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells

Moritz Horn, Virginia Kroef, Kira Allmeroth, Nicole Schuller, Stephan Miethe, Martin Peifer, Josef M. Penninger, Ulrich Elling and Martin S. Denzel

Oncotarget 2018 https://doi.org/10.18632/oncotarget.24305


Hexosamine pathway and (ER) protein quality control.

Denzel MS, Antebi A.

Curr Opin Cell Biol. 2015 Apr;33:14-8. doi: 10.1016/j.ceb.2014.10.001. Epub 2014 Oct 28. Review.


Hexosamine pathway metabolites enhance protein quality control and prolong life.

Denzel MS, Storm NJ, Gutschmidt A, Baddi R, Hinze Y, Jarosch E, Sommer T, Hoppe T, Antebi A.

Cell. 2014 Mar 13;156(6):1167-78. doi: 10.1016/j.cell.2014.01.061.


T-cadherin is essential for adiponectin-mediated revascularization.

Parker-Duffen JL, Nakamura K, Silver M, Kikuchi R, Tigges U, Yoshida S, Denzel MS, Ranscht B, Walsh K.

J Biol Chem. 2013 Aug 23;288(34):24886-97. doi: 10.1074/jbc.M113.454835. Epub 2013 Jul 3.


T-cadherin is critical for adiponectin-mediated cardioprotection in mice.

Denzel MS, Scimia MC, Zumstein PM, Walsh K, Ruiz-Lozano P, Ranscht B.

J Clin Invest. 2010 Dec;120(12):4342-52. doi: 10.1172/JCI43464.


Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer.

Denzel MS, Hebbard LW, Shostak G, Shapiro L, Cardiff RD, Ranscht B.

Clin Cancer Res. 2009 May 15;15(10):3256-64. 



Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage.

Johnsen M, Späth MR, Denzel MS, Göbel H, Kubacki T, Hoyer KJ, Hinze Y, Benzing T, Schermer B, Antebi A, Burst V, Müller RU.

PLoS One. 2016 Aug 24;11(8):e0161315.


Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE.

Aging Cell. 2016 Jun 16.


hESC Differentiation toward an Autonomic Neuronal Cell Fate Depends on Distinct Cues from the Co-Patterning Vasculature.

Acevedo LM, Lindquist JN, Walsh BM, Sia P, Cimadamore F, Chen C, Denzel M, Pernia CD, Ranscht B, Terskikh A, Snyder EY, Cheresh DA.

Stem Cell Reports. 2015 Jun 9;4(6):1075-88.


T-cadherin is essential for adiponectin-mediated revascularization.

Parker-Duffen JL, Nakamura K, Silver M, Kikuchi R, Tigges U, Yoshida S, Denzel MS, Ranscht B, Walsh K.

J Biol Chem. 2013 Aug 23;288(34):24886-97. 


Multivalent proteoglycan modulation of FGF mitogenic responses in perivascular cells.

Cattaruzza S, Ozerdem U, Denzel M, Ranscht B, Bulian P, Cavallaro U, Zanocco D, Colombatti A, Stallcup WB, Perris R.

Angiogenesis. 2013 Apr;16(2):309-27.


Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation.

Konter JM, Parker JL, Baez E, Li SZ, Ranscht B, Denzel M, Little FF, Nakamura K, Ouchi N, Fine A, Walsh K, Summer RS.

J Immunol. 2012 Jan 15;188(2):854-63. 


T-cadherin (Cdh13) in association with pancreatic β-cell granules contributes to second phase insulin secretion.

Tyrberg B, Miles P, Azizian KT, Denzel MS, Nieves ML, Monosov EZ, Levine F, Ranscht B.

Islets. 2011 Nov-Dec;3(6):327-37. 


The heme synthesis defect of mutants impaired in mitochondrial iron-sulfur protein biogenesis is caused by reversible inhibition of ferrochelatase.

Lange H, Mühlenhoff U, Denzel M, Kispal G, Lill R.

J Biol Chem. 2004 Jul 9;279(28):29101-8.